Depress and hold the power button for 30 seconds, release, then try powering up normally once again. This will reset the Fuze+.
Next thing to check is trying from the PC side. Plug in the USB cable and see if after a few seconds the display wakes up with the familiar USB icon.
If the player is frozen, it may not recognize the USB connection, and will not respond. In this case, disconnect, and try the soft reset once again. (USB connection is also handled by the Fuze+'s processor).
I have seen the device freeze requiring a reset like this. Compared against the earlier device, the delay before the display wakes up can be a little longer, about 8 seconds or so. The earlier machines would most often respond to the USB in 3-5 seconds.
If the device does not respond, starting with the device OFF, you can try holding the Volume Down button while connecting, and give it a few seconds to be recognized. This is how we can manually force an MSC connection, allowing you to cheak the drive for errors or reinstall the firmware, if need be.
If the above method does not work, contact Support at 1-866-SanDisk for further assistance in the US, or click on the red SanDisk logo in the upper left of this page, then click on Support for contact information.