Sandisk Extreme 500, Enable TRIM OSX?

Planning to upgrade my 2013 iMac with the Sandisk Extreme 500, and use it as system disk. My question should I enable TRIM or do nothing, El Capitan?

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The Extreme 500 is a removable USB drive. I do not think this is a good choice for a system drive. Also TRIM commands do not pass over USB.

below is how to enable TRIM for internal SSD on Mac