My e250 was bought new only a few years ago, less than 5 years. It was working perfectly fine until recently. Suddenly, when I turned it on, it only shows a black screen with a tiny (1 or 2 cm) long skinny horizontal line in the lower left part of the screen. I can’t even plug it in to my computer to try to fix it. What do I do? -alex96100-
I’ve had this happen rarely, but I have seen it. A reset should take care of it for you. Press and hold the power button for 20-30 secs. Release, then press it again momentarily to start it up. It should resume normally. Note that if you do this while the unit is on (and I recommend that you do), the unit will shut down after only a few seconds. Pay this no mind and continue the hold the power button for the full count to reset it. 
I held the button down for 1 minute. When I do that, it will show the logo and then go to the black screen.
I found a solution. It is at this link by the user TheMarkster: http://forums.sandisk.com/t5/All-other-MP3-players/Sansa-E250-Not-Starting/m-p/66638/highlight/true#M9944.
Good! Did it work?
Yes it did. My e250 is working just like before. sometimes it is a little slow, but that is okay. it never lasts more than a few seconds.
