after downloading security update: secure access failure reading the file's file

How long have you had the drive?  I ask because SecureAccess hasn’t been updated recently to the best of my knowledge.

Have you rebooted recently.  Simple answer but it works frequent enough to warrant asking.

Did you put the downloaded update on the USB drive before running it?

Did you back up your files before running the update?

Is there a chance a Windows 10 security app is blocking the new SecureAccess update?

Can you try the USB drive in a different pc?